Baruch Blumberg HUNT FOR A KILLER VIRUS HEPATITIS B

ISBN 069100692X

Size = 8vo - over 7¾" - 9¾" tall

About 375 million people are infected with the hepatitis B virus. It has killed more people than AIDS and also causes millions of cases of liver cancer. The discovery of this deadly virus and the vaccine against it - a vaccine that is sharply decreasing the infection rate worldwide and is probably the first effective cancer vaccine - was one of the great triumphs of 20th-century medicine. And it almost didn't happen.

With wit and insight, this scientific memoir and story of discovery describes how Baruch Blumberg and a team of researchers found a virus they were not looking for and created a vaccine for a disease they previously knew little about - work that took the author around the world and won him the Nobel Prize.

Blumberg and his collaborators were investigating relationships between gene distribution and disease susceptibility, research that was yielding interesting data but no real breakthroughs. Many viewed their work as more field trip than science. But, through decades of hard work and investigative twists and turns, their pursuit led to the hepatitis B antigen, the elusive virus itself, and, ultimately, the vaccine. As he takes the reader through the detective work that culminated in his incredible discovery, the author recounts with immediacy exciting moments in the lab and in the field - from a hair-raising flight to Africa to an unpleasant encounter with Alaskan sled dogs.

The hepatitis B story is more than a fascinating chronicle of a major discovery. What Blumberg followed to the virus was a trail of remarkable "accidents" that happen when scientists seek answers to interesting questions. Those events, combined with the investigator's determined persistence, resulted in studies that generated a pharmaceutical industry, have far-flung public-health applications, and saved millions of lives.

CONTENTS:

Introduction

1. Differences in Response to Disease
2. Inherited Variation and Susceptibility to Disease
3. Polymorphisms & Geography: Disease, Genetics, & Evolutionary Biology
4. We Discover a New Polymorphism: The Ag System
5. The Discovery of Australia Antigen
6. What Is Australia Antigen?
7. Identifying the Hepatitis B Virus
8. The Control of Posttransfusion Hepatitis
9. The Hepatitis B Vaccine
10. Hepatitis B Virus & Cancer of the Liver
11. What Is Now Known about HBV?
12. Back to Polymorphisms & Inherited Susceptibility to Disease
13. HBV & Its Connections: Current Research & the Future

Appendix:
1. Scientists & Staff at Fox Chase Cancer Center Referred to in the Text
2. Research on Hyaluronic Acid
3. The National Institutes of Health & the Funding of Basic Medical Research
4. Molecular Biology
5. A Gazetteer of Selected Place-Names Used in the Text

Index

244 pages. Hard cover with UNCLIPPED dust jacket. Ex-Library, very much cleaner & better than usual.

Weight = 900 g

BOOK / DUST JACKET CONDITION = VERY GOOD / FINE

NEW: This book has been designated by the seller as brand new.

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VERY GOOD: Shows some signs of wear and is no longer fresh. Attractive.

GOOD: Average used book with all pages present. Possible loose bindings, cocked spine or torn dust jackets.

FAIR: Obviously well-worn, but no text pages missing. May be without endpapers or title page. Markings do not interfere with readability.

POOR: All text is legible but may be soiled and have binding defects. Reading copies and binding copies fall into this category.